Tánaiste and Minister for Foreign Affairs Simon Harris has said that 15 Irish citizens who were seeking to leave Israel have been evacuated.
Mr Harris said in a statement that they left Israel in operations organised by Austria, and they are expected to arrive in Ireland in the coming days.
The United States joined Israel's war when it attacked three of Iran's key nuclear facilities overnight.
Israel began attacking Iran last Friday, claiming its long-time enemy was on the verge of developing nuclear weapons.
Iran, which has repeatedly said its nuclear programme is only for peaceful purposes, retaliated with missile and drone strikes on Israel.
Israel is widely acknowledged to be the only country in the Middle East in possession of nuclear weapons, a claim which it denies.
"Throughout this crisis, the Department of Foreign Affairs and Trade and our Embassy in Tel Aviv have remained in regular contact with Irish citizens in the region.
"We have worked closely with our EU and other partners to exchange information and coordinate our consular response to the situation."
He also urged Irish citizens who choose to stay in Iran and Israel to monitor developments.
"All citizens in the region should register with the nearest Irish embassy, if they have not already done so.
"Our embassies will remain in close contact with all citizens in Israel and Iran over the days and weeks ahead. Our wider political work on the developing situation also continues," Mr Harris said.
Earlier, the Tánaiste said that a "small number" of citizens also want to leave Iran, and work is under way to get them out too.
Mr Harris added that he spoke with the Iranian deputy foreign minister who was "very angry" at the actions of the US and Israel and described them as "aggressors".
He described the bombing of Iran's nuclear facilities by US B-2 stealth bombers as having made a "volatile situation even more dangerous".
He urged both sides to "step back from the brink" and de-escalate the situation.
However, Mr Harris said the Iranian deputy foreign minister felt that those who attacked his country need "to pay a price".
Taoiseach Micheál Martin called for an urgent need for de-escalation, dialogue and diplomacy after the US' attacks on Iran.
"We remain in close contact with international partners ahead of the EU Council", he added.
There is an urgent need for de-escalation, dialogue & diplomacy in the Middle East.
— Micheál Martin (@MichealMartinTD) June 22, 2025
Iran should unequivocally disavow the development of nuclear weapons.
A negotiated solution is the way forward. We remain in close contact with international partners ahead of the EU Council.
Mr Martin said it is now urgent that all "actors in the region" work to de-escalate the conflict.
"Diplomacy and dialogue is ultimately the only way to resolve these issues. Iran should commit not to develop nuclear weapons and disavowed its nuclear and uranium enrichment programme.
"Nuclear safety is an issue here. Modern warfare is very destructive. It is civilians who ultimately suffer and that is why we need an end to these wars and an end to conflict.
The Taoiseach said "we shouldn't lose sight of the catastrophe that is still unfolding in Gaza while the war between Iran and Israel continues".
Asked about Mr Trump's comments that there could be more bombings, he said that the US President has said to Iran that he wants dialogue first and he wants diplomacy.
"I think Iran should engage, particularly on the nuclear programme, it has been dragging on for years in terms of international diplomacy.
"The International Atomic Energy Agency did indicate that Iran was on course in terms of uranium enrichment and there is no need for that and Iran needs to pull back from that. get to the negotiating table and allow diplomacy and dialogue to resolve this".
He confirmed that the diplomatic corps are safely out of Iran and are working with European partners in terms of any Irish citizens who want to leave either Iran, Israel, or the Middle East.
He said the troops in Lebanon are safe.
"We are very conscious of them in what is a very volatile region and that is why de-escalation, dialogue and diplomacy is key because Iran has been a malign actor, it has to be said, in the Middle East in terms of supporting its proxies in Hamas, Hezbollah and the Houthis, and there is an opportunity in Lebanon - a new government there - to develop once and for all a solid governance of Lebanon which would allow greater stability".
Mr Harris is travelling to Brussels for a meeting of EU foreign ministers later today.
He added that "the way to address this was always through a negotiated solution. Any alternative to that is simply too dangerous for civilians, for the Middle East region and for global security."
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The Labour Party's leader Ivana Bacik said it was "horrific" to see developments in the Middle East overnight.
"All efforts must be made now at UN & international level to avert further escalation of conflict," she said.
Her party's Spokesperson on Foreign Affairs Duncan Smith said Mr Trump had "brought the world closer to all out war overnight".
"Ensuring Iran cannot develop a nuclear weapons capability should only be done through negotiation, the strong application of the IAEA inspections, and the broader non-proliferation regime," he added.
